Research
It is often difficult to clinically diagnosis autoimmune encephalitis because patients’ symptoms can be so widely varied. In the Sept. 2016, issue of The Lancet Neurology, Francesc Graus and colleagues proposed an initial diagnostic work-up relying on conventional neurological evaluation and standard diagnostic tests such as MRI, CSF sampling, and EEG. This approach would enable clinicians to make […]
One of the one of the largest university hospitals in Europe, Charite’, recorded significant progress in treating anti-NMDAR, including in patients who did not previously respond to treatment. Anti-NMDA receptor encephalitis is an inflammatory disease that affects the central nervous system. It is a rare autoimmune disease that results in the body producing antibodies against […]
The Autoimmune Encephalitis Alliance and Option Care Enterprises, Inc. are co-sponsoring a clinical trial at Mayo Clinic to evaluate intravenous immunoglobulin (IVIG) treatment in patients with autoimmune epilepsy who fail to benefit from standard epilepsy medications. This study, the first of its kind, builds on Mayo Clinic research advances identifying new approaches to the diagnosis and treatment […]
Autoimmune encephalitis in psychiatric institutions: current perspectives Bost et al. Neuropsychiatr Dis Treat. 2016; 12: 2775–2787. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089825/ Autoimmune encephalitis is a rare and newly described group of diseases involving autoantibodies directed against synaptic and neuronal cell surface antigens. As neurological symptoms are fairly well described in the literature, this review focuses on the nature of […]
The Autoimmune Encephalitis Alliance, along with Children’s National Health System, and the Childhood Arthritis and Rheumatology Research Alliance, co-sponsored the first International Pediatric Autoimmune Encephalitis Treatment Consensus Meeting at the Carnegie Endowment for International Peace in Washington, DC, on November 14. “The AE Alliance was honored to help bring many of the world’s leading experts […]
We get a lot of questions about known AE antibodies. Identification of antibodies on a cellular level has led to a reclassification and renaming of many diseases. Note that many people who have AE are antibody negative, which most in the medical community agree is because all antibodies simply have not yet been discovered. The Center for Autoimmune Neurology […]
Authors Chloe Bost,Olivier Pascual, and Jérôme Honnorat published the following in Dove Press an open access peer-reviewed publication devoted to medical and scientific research. Abstract: Autoimmune encephalitis is a rare and newly described group of diseases involving autoantibodies directed against synaptic and neuronal cell surface antigens. It comprises a wide range of neuropsychiatric symptoms. Sensitive and specific […]
The following is from The Lancet Neurology and is a response from Francesc Graus and Josep Dalmau first published in Sept. 2016. We thank Silvia Morbelli and colleagues for their comments on the role of brain 18fluorodeoxyglucose (18F-FDG) PET imaging in the management of autoimmune encephalitis. We agree about the potential use of 18F-FDG-PET in the diagnosis and evaluation […]
Abstract Reprinted from Health and Human Services Author Manuscript – Over the last 10 years the continual discovery of novel forms of encephalitis associated with antibodies to cell-surface or synaptic proteins has changed the paradigms for diagnosing and treating disorders that were previously unknown or mischaracterized. We review here the process of discovery, the symptoms, […]
In a new paper published in Neurology, an official journal of the American Academy of Neurology, Dr. Jenny J. Linnoila et al., “report the frequency of coexisting herpes viruses (herpes simplex virus 1 [HSV-1] or HSV-2, varicella zoster virus, Epstein-Barr virus [EBV], cytomegalovirus, or human herpes virus 6 [HHV-6]) andautoantibodies in patients with encephalitis (herpes or autoimmune) […]