Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition
June 30, 2012
Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition
Zuliani et al.
J Neurol Neurosurg Psychiatry. 2012 June; 83(6): 638-645.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348613/
The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely biomarkers for the presence of the tumour. Over the past 10 years, identification of autoimmune forms of encephalitis with antibodies against neuronal surface antigens, particularly the voltage gated potassium channel complex proteins or the glutamate N-methyl-D-aspartate receptor, have shown that CNS disorders, often without associated tumours, can be antibody mediated and benefit from immunomodulatory therapies.
– Abstract from ncbi.nlm.nih.gov
