Category: Psychiatry

Autoimmune encephalitis in psychiatric institutions: current perspectives

Autoimmune encephalitis in psychiatric institutions: current perspectives Bost et al. Neuropsychiatr Dis Treat. 2016; 12: 2775–2787. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089825/ Autoimmune encephalitis is a rare and newly described group of diseases involving autoantibodies directed against synaptic and neuronal cell surface antigens. As neurological symptoms are fairly well described in the literature, this review focuses on the nature of …

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Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A new challenging entity for consultation-liaison psychiatrist

Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A new challenging entity for consultation-liaison psychiatrist Maccaferri et al Brain Disord Ther 2016 May; 5(2):215 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959779/ Anti-N-methyl-D-aspartate receptor encephalitis is a relatively newly identified autoimmune neuropsychiatric disorder that predominantly affects children and young adults. Although psychiatric symptoms are highly prevalent and frequently severe, it has mainly been reported in neurological, but …

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A clinical approach to diagnosis of autoimmune encephalitis

A clinical approach to diagnosis of autoimmune encephalitis Graus F, Titulaer MJ, et al. Lancet Neurology 2016 Apr; 15(4):391-404 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066574/ Encephalitis is a severe inflammatory disorder of the brain with many possible causes and a complex differential diagnosis. Advances in autoimmune encephalitis research in the past 10 years have led to the identification of new …

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The diagnosis and treatment of autoimmune encephalitis

The diagnosis and treatment of autoimmune encephalitis Eric Lancaster J Clin Neurol. 2016 Jan; 12(1): 1-13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712273/ Autoimmune encephalitis causes subacute deficits of memory and cognition, often followed by suppressed level of consciousness or coma. A careful history and examination may show early clues to particular autoimmune causes, such as neuromyotonia, hyperekplexia, psychosis, dystonia, or …

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Anti-NMDA Receptor Encephalitis in Psychiatry

Anti-NMDA Receptor Encephalitis in Psychiatry Kayser et al. Curr Psychiatry Rev. 2011; 7(3):189-193. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983958/ “Anti-NMDA receptor encephalitis is an autoimmune disorder in which antibodies attack NMDA (N-methyl-D-aspartate)-type glutamate receptors at central neuronal synapses. Symptoms include a highly characteristic set of neurologic deficits, but also prominent psychiatric manifestations that often bring mental health professionals into the …

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Anti-N-methyl-D-aspartate receptor encephalitis: A targeted review of clinical presentation, diagnosis, and approaches to psychopharmacologic management

Anti-N-methyl-D-aspartate receptor encephalitis: A targeted review of clinical presentation, diagnosis, and approaches to psychopharmacologic management Kruse et al Annals of Clinical Psychiatry. 2014 Feb;26(1):e1-9 https://www.researchgate.net/profile/Michael_Davis27/publication/260118368_Anti-N-methyl-D-aspartate_receptor_encephalitis_A_targeted_review_of_clinical_presentation_diagnosis_and_approaches_to_psychopharmacologic_management/links/559b423708ae5d8f39380611/Anti-N-methyl-D-aspartate-receptor-encephalitis-A-targeted-review-of-clinical-presentation-diagnosis-and-approaches-to-psychopharmacologic-management.pdf Anti-N-methyl-d-aspartate receptor encephalitis was formally described in 2007 and includes a range of psychiatric and neurologic symptoms. Most patients with anti-NMDAR encephalitis initially present to psychiatrists for diagnosis and treatment. …

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Autoimmune Encephalitis

Autoimmune Encephalitis Leypoldt F, Wandinger K-P, Bien CG, Dalmau J. European neurological review. 2013;8(1):31-37. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910513/ The term autoimmune encephalitis is used to describe a group of disorders characterised by symptoms of limbic and extra-limbic dysfunction occurring in association with antibodies against synaptic antigens and proteins localised on the neuronal cell surface. Since many patients respond …

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Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study

Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study Titulaer MJ, McCracken L, et al. Lancet Neurology; London 12.2 (Feb 2013): 157-65. https://www.ncbi.nlm.nih.gov/pubmed/23290630 Anti-NMDA receptor encephalitis is an autoimmune disorder in which the use of immunotherapy and the long-term outcome have not been defined. We aimed to …

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Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders

Dale et al Brain. 2012 Nov;135(Pt11):3453-68. https://academic.oup.com/brain/article/135/11/3453/272463 Recent reports of autoantibodies that bind to neuronal surface receptors or synaptic proteins have defined treatable forms of autoimmune encephalitis. Despite these developments, many cases of encephalitis remain unexplained. We have previously described a basal ganglia encephalitis with dominant movement and psychiatric disease, and proposed an autoimmune aetiology. …

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Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition

Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition Zuliani et al. J Neurol Neurosurg Psychiatry. 2012 June; 83(6): 638-645. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348613/ The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely biomarkers for …

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